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无锡肛瘘炎治疗医院要多少钱飞度快交流网无锡患了痔疮治疗医院要多少钱

2018年04月23日 17:16:19
来源:四川新闻网
飞度技术健康管家

江阴市中医院治疗直肠前突价格One common protein-contact prediction is that, if the side chain of one member of a pair of amino acids brought close together by folding is long, then that of the other member will be short, and vice versa.一种比较普通的蛋白质接触预测就是,如果一对氨基酸的一个侧链折叠后很长,那么里一个侧链就会很短,反之亦然。In other words, the sum of the two lengths is constant.换句话说,两个氨基酸侧链的总长度是恒定的。If you have but a single protein sequence available, knowing this is not much use.只知道一个蛋白质中氨基酸分子的排列顺序没有太大用处。Recent developments in genomics, however, mean that the DNA sequences of lots of different species are now available.不过基因组学最近的进展表示,现在许多不同物种的DNA分子的顺序是可以获取的。Since DNA encodes the amino-acid sequences of an organism’s proteins, the composition of those species’ proteins is now known, too.因为DNA分子编码生物体蛋白质中氨基酸分子的顺序,那么这些物种的蛋白质的组成也就可以获悉。That means slightly different versions, from related species, of what is essentially the same protein can be compared.这意味着,功能相同,但属于近缘物种的,在组成上稍有不同的蛋白质,可以进行比较。The latest version of Rosetta does so, looking for co-variation (eg, in this case, two places along the length of the proteins’ chains where a shortening of an amino acid’s side chain in one is always accompanied by a lengthening of it in the other).最新版本的Rosetta所做的就是寻找蛋白质的相关变异。(比如:在这个例子中,沿着蛋白质链长度方向的两个地方,如果一个氨基酸的侧链变短了,另一个氨基酸的侧链就会变长)。In this way, it can identify parts of the folded structure that are close together.用这种方法可以辨别紧密接触的折叠氨基酸的结构。Though it is still early days, the method seems to work.虽然现在是初期阶段,不过这个方法还是有用的。None of the 614 structures Dr Baker modelled most recently has yet been elucidated by crystallography or NMR, but six of the previous 58 have.Baker士近期所建立的614种蛋白质模型中,没有被晶体学或者磁共振所实的,但是之前的58个模型中有6个被实。In each case the prediction closely matched reality.在每一个模型中,预测的蛋白质结构与实际蛋白质分子的结构相差无几。Moreover, when used to “hindcast” the shapes of 81 proteins with known structures, the protein-contact-prediction version of Rosetta got them all right.此外,应用最新版本的Rosetta对已知结构的81个蛋白质进行“追算”,结果表明,蛋白质接触预测的蛋白质结构都是正确。There is a limitation, though.然而它是有局限性的。Of the genomes well-enough known to use for this trick, 88,000 belong to bacteria, the most speciose type of life on Earth.已熟知的,并且适用这种方法的基因组中,有88000种属于地球上最多的物种-细菌。Only 4,000 belong to eukaryotes—the branch of life, made of complex cells, which includes plants, fungi and animals.仅仅有4000中属于真核生物,生命的另一种形式。它是由复杂的细胞组成,有动物、植物、真菌。There are, then, not yet enough relatives of human beings in the mix to look for the co-variation Dr Baker’s method relies on.然而,在这个大家族中,没有足够多的与人类具有亲缘关系的物种,所以无法研究相关变异,而这是 Baker士的方法所需要的条件。Others think they have an answer to that problem.对于这个问题,其他人认为他们有解决方法。They are trying to extend protein-contact prediction to look for relationships between more than two amino acids in a chain.他们尝试扩展蛋白质接触预测的范围,在一条链中寻找不止2个氨基酸的相互关系。This would reduce the number of related proteins needed to draw structural inferences and might thus bring human proteins within range of the technique.这将会减少结构上不同的相关蛋白质的数目,并可能因此将人类蛋白质引入技术范围内。But to do so, you need a different computational approach.但是如果这么做的话,就需要一个不同的计算方法。Those attempting it are testing out the branch of artificial intelligence known as deep learning.想要尝试的人正在对以深度学习为人熟知的人工智能的分技术进行检测。Deep learning employs pieces of software called artificial neural networks to fossick out otherwise-abstruse patterns.深度学习采用一些称为人工神经网络的软件来搜寻其他深奥的模式。It is the basis of image- and speech-recognition programs, and also of the game-playing programs that have recently beaten human champions at Go and poker.它是图像和语音识别程序的基础,也是最近在围棋和纸牌游戏中打败人类冠军的游戏程序的基础。Jianlin Cheng, of the University of Missouri, in Columbia, who was one of the first to apply deep learning in this way, says such programs should be able to spot correlations between three, four or more amino acids, and thus need fewer related proteins to predict structures.哥伦比亚的密苏里州的大学的程建林最先把深度学习应用到这个方面。他说,这个程序能够找到三个、四个或者更多氨基酸之间的相互关性。并且需要更少的相关的蛋白质分子来预测其结构。Jinbo Xu, of the Toyota Technological Institute in Chicago, claims to have achieved this aly.芝加哥丰田技术研究所的徐金波声称现在已经达到这种技术水平。He and his colleagues published their method in PLOS Computational Biology, in January, and it is now being tested.他和他同事在一月份将这一方法发表在《PLOS计算生物学》上,现处于测试阶段。If the deep-learning approach to protein folding lives up to its promise, the number of known protein structures should multiply rapidly.对于蛋白质分子折叠,如果深度学习的方法达到了预期的效果,那么已知蛋白质结构的数目应该会迅速增加。More importantly, so should the number that belong to human proteins.更为重要的是,对人类蛋白质结构的了解也会增加。That will be of immediate value to drug makers.对于制药公司来说将会有即时的好处。It will also help biologists understand better the fundamental workings of cells—and thus what, at a molecular level, it truly means to be alive.这也将会帮助生物学家更好的理解细胞的基本功能。如此一来,意味着分子水平的研究真正开始了。考研英语时事阅读 /201704/504209无锡市人民医院痔疮第一, 迷你对话A: How was the party last night?昨天的晚会怎么样?B: It can’t be worse. My friend Peter made a monkey out of me.糟糕透顶了。我朋友Peter捉弄了我。A: Really?真的吗?B: Yeah, he told me the party was formal, so I wore a suit an d tie. But everybody else there was wearing a T-shirt and blue jeans. It sure make me feel like a fool.可不,他告诉我那个晚会是正式的,所以我就穿了西装,打了领带,可是其他人穿T恤衫,这真使我感觉自己像个傻瓜似的。第二, 地道表达make a monkey out of somebody1. 解词释义Make a monkey out of somebody的意思是“使出丑,耍弄,愚弄”的意思。2. 拓展范例e.g. He made a monkey out of me with his wisecracks about my abilities.他讽刺挖苦我的能力,出尽我的洋相。e.g. I suddenly realized that I had been made a monkey out of by opponents.我突然间意识到我被我的对手耍了。e.g. I dont like being made a monkey out of in front of my friends; dont play your jokes on me again when we have guests.我不喜欢在朋友面前被人戏弄。以后客人在场时,你不要再和我开玩笑。e.g. The children wont get to make a monkey out of her. Shes an old hand at baby-sitting.孩子们是不会跟她胡闹的,她是看孩子的老手了。e.g. When you see Sarah, dont you dare make a monkey out of her or Ill punch you.看见莎拉不要拿她开玩笑,不然小心我揍你。 /201704/504245今天要讲的三个习惯用语都具有相同的意思;都表示生气或者是愤怒。我们先来讲第一个:hot under the collar。Hot就是热;collar就是衣的领子。要是一个人很生气,他会觉得他的脖子很热,被衣的领子裹得很紧使他感到很难受。下面例句里说话的人和他的太太出去旅行,回到家里看到他的邻居的两只在他们院子里到处乱跑。他和他太太看到这种情况,顿时感到非常生气,他说:例句-1:We really go hot under the collar when we saw what those dogs have done to those flowers we worked so hard to grow. They dug some up and rolled around on top of others. Now our flower beds are a mess.我们看到这两只把我们辛辛苦苦种好的花弄成那个样子的时候,我们真是非常生气。它们把一些花从地里挖了出来,还在一些花上滚来滚去。现在我们的花床都给弄得一团糟了。第二个习惯用语是flip ones wig。Flip就是扔掉;wig就是头发太少的人为了遮丑而戴的假发。Flip ones wig就是气得把假发也给扔了;也就是一个人对让他生气的人或者是引起他生气的事情作出的强烈反应。我们也来给大家举个例子,例句里说话的人和他伙伴Eddy合作经营一个小的首饰店。他有一个新的主意来推销他们的首饰,但是Eddy要比他保守多了,所以他怕Eddy会对他想法根本不感兴趣。我们来听听他是怎么样对Eddy说的:例句-2:Say, Eddy, let me try a new idea that I have to get more customers by spending some money on newspapers advertising. You may flip your wig about my plan, but we need to do something quick to get more people to look at our goods.嘿,Eddy,能不能让我试一试我的一个新的想法?那就是花点钱在报纸上做广告。这样可以吸引更多的顾客。你可能会强烈地反对我的主意,但是我们得快点采取措施来吸引更多的人来看看我们的货品。今天要讲的第三个习惯用语是to raise the roof。Raise是一个动词,意思是把什么东西抬高;roof就是房子的屋顶。To raise the roof它的意思是:一个人很生气地大声抱怨;他的声音之大简直可以把房子的屋顶都抬了起来。这当然是夸大的说法。但是to raise the roof这个习惯用语可以说明一个人有多么的生气。我们也来给大家举个例子说明to raise the roof这个习惯用语是怎么用的。例句里说话的人在告诉他的朋友他十七岁的时候发生的一件事。有一天他问他的爸爸借了一辆车,带着他特别喜欢的女朋友去看电影。在停车的时候他不小心把车的挡泥板擦到旁边一辆车上,有的地方都凹了进去。你可以想象第二天早上,他爸爸看到车子受到损伤的时候会有多么生气。这个人对他的朋友说:例句-3:When Dad saw those dents, he raised the roof with me. I did not get to use the car the whole summer and I had to pay to fix the damage with money I made by mowing the lawns around the neighborhood.我爸爸看到车上这些凹痕时恼火极了。我整个夏天就没有能再用这辆车,而且我还得用我替邻居割草赚来的钱付修理费。 /201205/182804无锡肛裂痔疮医院

无锡市肛泰医院治疗直肠黏膜内脱垂价格无锡混合痔治疗——Promise?——Promise. ——你确定吗? ——我保。Absolutely!Definitely!那当然It's certain./It's for sure!/Sure thing!No doubt! There‘s no doubt about it.毫无疑问。◎点击播放器下方“进入MP3进入下载界面”可下载音频◎ /201104/130499In the bookstore 在书店里一、talk show1、What are the titles, and who are the publishers ?书名和出版社是什么?title:这里是书名的意思,除此之外有“冠军;标题;头衔;权利;字幕”的意思。这里提一下,当“标题”讲的时候,与之向应的“副标题”是subtitlepublisher:出版社 publish:出版Eg:这本书是何时出版的?When did this book published?2、The new series of Bookworm sells well.新的《书虫》系列卖的很好。Series:系列,连续 a series of 一系列的 某物卖得好:主语(物)+ sell eg:Jeans of this color sells well.这种颜色的牛仔裤卖的很好。3、The paperback second edition also has become a bestseller.平装本的第二版也成为了畅销书。paperback:平装本 hardback:精装本edition:版本 second edition 第二版bestseller: 畅销书4、There are also lots of used book shops online.网上也有不少二手书书店。used book shops:二手书店 于此对应:新书 new bookused:二手的 used bike 二手自行车5、I am sorry that the book you ordered is out of stock.很抱歉你订的书目前缺货。out of stock:缺货 in stock 有存货order: 预定6、This book is selling at a discount at present这本书目前打折出售。sell at a discount:打折出售discount store:打折店at a discount of 70%:打七折 也可以说30% off7、The preface and the appendix is not so well, but the content of the book is wonderful.虽然这本书的前言和附录不是很好,但是内容很精。preface:前言;为……作序appendix:附录;在医学上表示:阑尾content:内容 /201104/130565无锡哪个医院看痔疮好Finance and Economics财经Economic Development: Shrink wrap经济发展:收缩包装Why the history of economic growth should be all about recessions?为什么经济增长的历史应该都是与经济衰退相关?“Throughout history, poverty is the normal condition of man,” wrote Robert Heinlein, a science-fiction writer.一个名为罗伯特·海因莱因( Robert Heinlein )的科幻作家写到,“纵观历史,贫穷是人们的常态”。Until the 18th century, global GDP per person was stuck between 5 and ,100, around the same income level as the World Banks current poverty line of .90 a day.直到18世纪,全球GDP每人都卡在725美元和1100美元之间,大约和世界目前每天1.90美元贫困线一样。But global income levels per person have since accelerated, from around ,100 in 1800 to ,600 in 1950, and over ,000 today.但是全球收入水平每人已经增长了,从1800年1100美元到1950年3600美元,到今天超过了10万美元。Economists have long tried to explain this sudden surge in output.经济学家长久以来一直试图解释这种收入上的突然增长。Most theories have focused on the factors driving long-term economic growth such as the quantity and productivity of labour and capital.大部分理论都集中在促进经济长期增长的因素如劳动和资本的质量和生产力。But a new paper takes a different tack: faster growth is not due to bigger booms, but to less shrinking in recessions.但是一项新的研究有了不同的看法:更快的增长并不是由于大繁荣,而是由于萧条中更少的衰退。Stephen Broadberry of Oxford University and John Wallis of the University of Maryland have taken data for 18 countries in Europe and the New World, some from as far back as the 13th century.牛津大学的斯蒂芬·布劳德伯利(Stephen Broadberry)和马里兰大学的约翰·沃利斯(John Wallis)把18世纪欧洲和新世界,还有一些早至13世纪的数据收取了。考研英语时事阅读 /201706/515822无锡慢性便秘治疗医院要多少钱

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